Serotonin is commonly known as a key chemical for happiness and well-being. It's a neurotransmitter, one of the brain's four main chemicals, which includes acetylcholine, dopamine, and GABA, that transmits signals from the brain to the body.
Serotonin, or ser-o-TOE-nin, is one of the neurotransmitters that carry signals along nerves. Remarkably, 80 to 90 percent of serotonin is located in the gastrointestinal tract, playing a vital role in both brain and bodily functions.
This chemical is produced through a biochemical conversion process. Tryptophan, a basic building block of proteins, combines with hydroxylase, triggering a chemical reaction that results in the creation of 5-hydroxytryptamine (5-HTP), also known as serotonin.
Serotonin's importance is multifaceted. It's best known for mood regulation, but it also maintains normal appetite, digestion, social behavior, and sleep patterns. In terms of cognitive functions, it mainly influences learning and memory.
A deficiency in serotonin can lead to significant internal communication issues, disrupting nerve signal transmission. This can result in various psychological problems, including depression, decreased sexual desire and function, as well as impaired sleep, memory, and learning abilities.
Outside of the brain, serotonin affects the functioning of the cardiovascular system, endocrine (n-doe-crin) system, and various muscles. Per WebMD, there is some evidence that “a defect within the serotonin system may be one underlying cause of SIDS (sudden infant death syndrome).”
Serotonin Syndrome
Serotonin syndrome is the mirror opposite of serotonin deficiency. As mentioned, it is serotonin deficiency that causes depression. It is important to remember this point, as deficiency is much more widespread than Serotonin Syndrome.
So again, serotonin deficiency = depression and excessive serotonin = other sicknesses (or Serotonin Syndrome.)
Related Article: How to Increase Your Serotonin Levels
Serotonin Syndrome on the other hand, occurs when there’s an excessive amount of nerve cell activity, which can be a fatal condition.
What causes an imbalance?
Serotonin Syndrome may occur if you’re taking certain medications known to affect the production of serotonin. Per WebMD, “The greatest risk of serotonin syndrome occurs if you are taking two or more drugs and/or supplements together that influence serotonin.” Most frequently, serotonin syndrome happens when someone “first (starts) a medicine or (increases) the dose.”
Prescription medications are the primary cause of serotonin syndrome. The most commonly prescribed class of medications that affect serotonin levels are antidepressants.
SSRIs
SSRIs, or selective serotonin reuptake inhibitors, work by blocking reabsorption of the chemical in the brain; increasing the amount of serotonin available. SSRIs are “selective” in that they do not affect other neurotransmitters.
Common SSRIs include Citalopram (Celexa), Escitalopram (Lexapro), Fluoxetine (Prozac), Paroxetine (Paxil or Pexeva), Sertraline (Zoloft), and Vilazodone (Viibryd).
SNRIs
SNRIs, or serotonin and norepinephrine (nor-ep-ih-NEF-rin) reuptake inhibitors, work by blocking reabsorption of serotonin and norepinephrine. Deficiencies of the latter chemical “can leave you feeling fatigued and mentally foggy, with little interest in life.”
SNRIs are a treatment option when a patient is non-responsive to SSRIs – something that occurs in approximately half of individuals diagnosed with depression. SNRIs may also be effective against ADHD (attention deficit hyperactivity disorder), GAD (generalized anxiety disorder), and CFS (chronic fatigue syndrome).
Common SNRIs include: Desvenlafaxine (Pristiq, Khedezla), Duloxetine (Cymbalta), Levomilnacipran (Fetzima), and Venlafaxine (Effexor and Effexor XR).
Other Drugs
Here are a few other prescription and over-the-counter drugs that can raise serotonin levels or increase the risk of disease: Monoamine oxidase inhibitors (MAOIs), painkillers, migraine medications, nausea medications, cough suppressants (mostly Dextromethorphan), and illegal drugs (LSD, cocaine), and certain supplements (St. John’s Wort and ginseng).
“Precursors to Serotonin”
As mentioned, serotonin is produced via biological reaction within the body. It is important that we mention some “precursors,” or “other stuff” (supplements, vitamins, minerals, etc.) that can increase the levels of serotonin.
Here are a few things known or thought to increase the chemical in the blood: vitamins B6 and B12, vitamins C and D, folate, magnesium, DHA (in fish oil), inositol, normal thyroid function, and intense exercise.
Why know this?
It’s important to know because depression is one of the most common medical conditions in the world. More people are diagnosed with depression (and anxiety) than any other.
Third, because Serotonin Deficiency is a potentially-fatal condition.
Lastly, because we have a healthcare system known for overprescribing antidepressants (and other prescription drugs.) While these drugs may indeed be helpful to some, others face the risk of dependency or worse.
Symptoms:
Symptoms often begin within a few hours of taking a new medication that affects serotonin levels or excessively increasing the dose you are already taking.
Here are some of the more common signs and symptoms of Serotonin Syndrome, per WebMD:
- Confusion
- Headache
- Nausea, diarrhea, and/or vomiting
- Tremor
- Loss of muscle coordination
- Shivering and/or heavy sweating
- High fever (life-threatening)
- Seizures (life-threatening)
- Loss of consciousness (life-threatening)
- Irregular heartbeat (life-threatening)
Source: https://www.powerofpositivity.com/10-signs-serotonin-syndrome/
